HIPEC for Ovarian Cancer

Memorial Sloan-Kettering Cancer Center, New York, NY

Gynecologic oncologist Oliver Zivanovic describes the growing program at Memorial Sloan-Kettering Cancer Center to assess heated intraperitoneal chemotherapy (HIPEC) to treat ovarian cancer in women undergoing cytoreductive surgery (performed to remove cancerous tissue from the abdominal cavity).


I am a surgeon with specialized training in cancers of the colon, rectum, anus, and appendix. The focuses of my practice include minimally invasive techniques for colorectal cancer (including laparoscopy, single-incision laparoscopy, and robotic surgery), avoiding colostomy while preserving bowel, bladder, and sexual function, and the management of peritoneal surface malignancies (including pseudomyxoma peritonei and mesothelioma).

My clinical research involves prospective clinical trials of new technology and surgical techniques for advanced colorectal and appendiceal malignancies, as well as optimizing surgical margins and lymph node retrieval for colon and rectal cancers. I am the primary investigator for the ICARuS Trial (Intraperitoneal Chemotherapy After cytoReductive Surgery). This is a randomized clinical trial investigating the benefit of intraperitoneal chemotherapy for metastatic appendiceal and colorectal cancer. It will be the first-ever prospective trial of treatment for appendix cancer worldwide and the first randomized trial of intraperitoneal chemotherapy for colorectal cancer in the United States.

I have authored papers on a variety of subjects including cytoreductive surgery, intraperitoneal chemotherapy, minimally invasive surgery, sphincter-sparing rectal surgery, mechanisms of tumor progression, and predictors of outcome following surgery. I serve as an instructor at Weill Cornell Medical College for other surgeons learning laparoscopic colon and rectal surgery. I have completed six races for Fred’s Team — NYC Half Marathons each year from 2010 through 2013 and NYC Marathons in 2010 and 2011 — and in so doing have raised more than $30,000 to support cancer research at Memorial Sloan-Kettering. I will be running the 2013 NYC Marathon for Fred's Team in November.

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Hyperthermic Intraperitoneal Chemotherapy for Cancers of the Appendix, Colon, or Rectum

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